Prepare the pasta according to the package instructions. Drain well and place in a large casserole dish.
Add the tofu, soy milk, tahini, lemon juice, miso, garlic powder, onion powder, and nutritional yeast into the food processor. Blend until smooth and creamy consistency, making sure to scrap the sides.
Preheat oven to 350 degrees.
Mix the tofu mixture in with the macaroni.
In a small skillet, add the butter and bread crumbs, mixing to coat well. Spread the bread crumbs over the top of the macaroni mixture. Season with salt and pepper.
Bake in the oven for 20-25 minutes or until lightly toasted.